![]() Inter-state cargo logistics is now a grave opposition to these entrepreneurs. ![]() It was discovered that the state government exploits these logistics companies dry with one payment or the other and so they have no option but to correspondingly increase their fares. They stated how the cost of deliveries through dispatch riders within the same city are incredibly high and continue to increase. These businesses have the same challenge with logistics. ![]() They deal in buying and selling of smart phones and gadgets in Ikeja computer village Lagos, and they represent majority of similar businesses. We had a chat with two entrepreneurs Hills-Tech Stores and The Salesman Phones & Gadgets. In a discussion with some Nigerian entrepreneurs, the foundation found that logistics poses a major challenge for entrepreneurs in commerce. We started advocacy to get the public sector to understand the need for businesses to do well. Quintessentially policy-based logistics challenges. On today’s episode of #TEFAdvocacy, we will be discussing challenges affecting entrepreneurs in Nigeria. African entrepreneurs are the heart of the foundation and what bothers these entrepreneurs bothers us all at TEF. Disruption of murine TEF-1 gene results in fetal death.The Tony Elumelu foundation is the leading champion of entrepreneurship in Africa. ![]() Although TEF-1 is expressed ubiquitously during embryogenesis, its expression is limited to adult kidney, heart, brain, skeletal muscle, and lungs. TEF-1 induced transcription requires a limiting transcriptional intermediary factor (TIF) and a TATA-binding protein associated factor (hTAFIIs). The C-terminal portion contains the transactivation domain and a zinc finger-like motif that is thought to be involved in protein dimerization or interaction with additional transcription factors. The N-terminal basic portion of TEF-1 contains the DBD. However, the DNA binding activities of TEF-1 are modulated by sequences outside the DBD. Comparison of various enhancers indicates that TEF-1 binds to highly degenerate DNA sequences and cooperatively interacts with tandem repeats of its binding sites, which increases its enhancer activity. TEF-1 was identified as a HeLa cell transcriptional activator that bound, via its TEA domain, to the GT-IIC and Sph enhancer elements. ![]() TEF-1 ( t ranscription e nhancer f actor - 1 ) is a member of a family of transcription factors that contain an evolutionarily conserved DNA binding domain (DBD), TEA/ATTS. ![]()
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